Five people were killed in two states after at least 13 twisters damaged homes, splintered barns and toppled trees in parts of Alabama, Louisiana, Mississippi and Tennessee, the National Weather Service confirmed.
At least a dozen more people were injured early Wednesday, adding to a seemingly biblical onslaught of drought, flood and fire plaguing the South.
The storms tore through just as firefighters began to get control of wildfires that killed seven and damaged or wiped out more than 700 homes and businesses around the resort town of Gatlinburg, Tennessee. In Alabama, the weather system dumped more than 2 inches of rain in areas that had been parched by months of choking drought.
"It looks like the rapture happened up there," said church member Steve Hall, referring to the end-times belief of many Christians.
"Are we thinking the Lord is trying to get our attention?" said the pastor, Roger Little.
The National Weather Service was assessing damage from multiple possible tornadoes across the region. At least five hit Alabama, and three more struck southern Tennessee, and one confirmed in Louisiana and at least four in Mississippi, forecasters said.
A possible tornado was spotted on the ground Wednesday a few miles from Atlanta, and flights were briefly delayed at the city's main airport, but no major damage occurred.
Three people were killed and one person critically injured in an Alabama mobile home after an apparent twister hit tiny Rosalie, about 115 miles northeast of Birmingham, said Jackson County Chief Deputy Rocky Harnen.
A suspected tornado was responsible for the death of a husband and wife in southern Tennessee's Polk County, while an unknown number of others were injured, said Tennessee Emergency Management Agency spokesman Dean Flener. No details were immediately available.
The Daily Post-Athenian in Athens, Tennessee, reported the Meigs County sheriff's office said lightning is suspected as the cause of two deaths in a mobile home fire.
Shirley Knight, whose family owns a small propane business in Rosalie, said the storm crashed in on them in the middle of the night. Daybreak revealed mangled sheets of metal, insulation and a ladder hanging in trees.
"We had a plaza, a service station and several buildings connected together, and it's all gone," said Knight, adding that the storm also destroyed a church and damaged buildings at a nearby Christmas tree farm.
The same storm apparently hit a closed day care center in the nearby community of Ider, injuring seven people, including three children who had left their mobile home to seek shelter, said Anthony Clifton, DeKalb County emergency management director.
Alabama Gov. Robert Bentley issued a state of emergency because of the storms.
Meanwhile, thousands of people were without power, including up to 45,000 homes at one point in Alabama. Many schools dismissed early in Alabama and Georgia to avoid having students on the road in buses as storms continued to roll across the region Wednesday.
Teams from the National Weather Service confirmed that at least two weak tornadoes struck western Alabama, and meteorologist Kurt Weber from Huntsville said they were assessing damage tracks from at least four other possible tornadoes.
Tornadoes and hail also were reported Tuesday in Louisiana and Mississippi. The National Weather Service in Jackson, Mississippi, counted six confirmed tornadoes in areas of the state it monitors.
Despite dozens of tornado warnings, authorities said no one was injured in Mississippi, but six homes were reported destroyed in one southeastern county. Mississippi Public Service Commissioner Brandon Presley said he came upon a UPS truck that was blown onto its side and hit a pickup truck.
"I've never driven through something like this in my life," Presley said.
Torrential rains filled waterways and ponds that were drying up just days ago. Police in the northwest Alabama city of Florence put out barriers to block roads that flooded with as much as 2 feet of water when fallen leaves clogged drainage systems during torrential downpours. Streams were cresting in western Alabama after as much as 4 inches of rain.
All that water will only help snuff out wildfires that have burned thousands of acres across the region in recent weeks.
Rain provided some relief for the Gatlinburg, Tennessee, area Wednesday. All the wildfires in the city are now out, but some are still smoldering, according to the Tennessee Emergency Management Agency. Firefighters were still checking for hotspots, Gatlinburg Fire Chief Greg Miller said.
Some people had to deal with more than one problem.
A six-person crew that spent all Tuesday night fighting fires in Gatlinburg left the fire scene only to help respond to a tornado in McMinn County, Tennessee, said Fire Chief Bill Roach of Englewood, Tennessee.
"They're wore out," Roach said. "They've had very little sleep, and I know I've had two hours since Monday morning. We're to our limits."
Associated Press writers Bernard McGhee in Atlanta; Bill Fuller in New Orleans; Rebecca Yonker in Louisville, Kentucky; Jeff Amy in Jackson, Mississippi; Seanna Adcox in Columbia, South Carolina; and Jonathan Mattise in Nashville, Tennessee, contributed to this report.